
Overview
and History of CLOMIMED 50 (Clomiphene citrate)
CLOMIMED
50 (Clomiphene citrate) belongs to a category of drugs known as selective
Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators are a diverse
group which belongs to an even broader class
of drugs which act on the estrogen receptor (ER). Another subcategory of drug under the
anti-estrogens category is known as aromatase inhibitors (AIs), such as AROMAMED
25 (Exemestane) and ARIMIMED
1 (Anastrozole). AIs and SERMs make up anti-estrogens. Aromatase
inhibitors (AIs) are very different from SERMs in their action and how they
deal with the issues of estrogen control.
CLOMIMED
50 (Clomiphene citrate) is classified as an anti-Estrogen, but in
reality, it is utilized for the treatment of female infertility resulting from
ovulation failure (anovulatory infertility). Meaning, CLOMIMED
50 (Clomiphene citrate) primarily used in medicine as a non-steroidal
ovulatory stimulant for women. CLOMIMED
50 (Clomiphene citrate) is a SERM, the same like NOLVAMED
20 (Tamoxifen citrate) and it exhibits mixed Estrogen agonist and
antagonist effects in various tissues of the body. Both NOLVAMED
20 (Tamoxifen citrate) and CLOMIMED
50 (Clomiphene citrate) act as an Estrogen antagonist in the
hypothalamus, pituitary gland, ovaries, endometrium, vagina, and cervix. CLOMIMED
50 (Clomiphene citrate) serves to mitigate (inhibit or
block) the action of Estrogen in these tissues and areas of the body. In both,
males and females, its Estrogen antagonistic effect on the hypothalamus will
trigger a release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating
Hormone). These two hormones in men are the signal hormones that signal the
testes to begin or increase its production of Testosterone, and this total
process is known as the HPTA (Hypothalamic Pituitary Testicular Axis). That is
almost the same with female users, except LH and FSH will trigger the release
of eggs from the ovaries (known as follicular rupture), which would lead to increased
chances of contraception. This total process in females is known as the HPOA
(Hypothalamic Pituitary Ovarian Axis).
Again, both NOLVAMED
20 (Tamoxifen citrate) and CLOMIMED
50 (Clomiphene citrate) could be considered an Estrogen that acts as a ‘fake’ Estrogen in areas
of the body, such as breast tissue (the aim is to block the effects of ‘real’
Estrogen, while it also works as an actual Estrogen in other areas of the
body). For athletes and bodybuilders that are for most males, CLOMIMED
50 (Clomiphene citrate) can serve as an effective anti-Estrogen to mitigate one particular
unwanted side effect of Estrogen as a result of the use of aromatizable
anabolic steroids (such as TESTOMED
E 250 (Testosterone Enanthate), DIANAMED
10 (Methandienone), EQUIMED
250 (Boldenone undecylenate), etc.). This unwanted side effect is gynecomastia, which refers to the
development of breast tissue resulting from excess Estrogen levels in the body.
CLOMIMED
50 (Clomiphene citrate) antagonistic effects on the hypothalamus resulting
in the increased production of gonadotropins LH and FSH, that is the reason CLOMIMED
50 (Clomiphene citrate) can effectively be used to increase endogenous
testosterone production in males. This is especially so for the anabolic
steroid using individuals that want to restore proper hormonal function during
the weeks of Post Cycle Therapy (PCT). Usually, during PCT a combination of NOLVAMED
20 (Tamoxifen citrate), CLOMIMED
50 (Clomiphene citrate), and HCG (Human Chorionic Gonadotropin) is used for several weeks, and
although much better more modern protocols have been developed, this
long-standing traditional PCT protocol is still very effective.
All of the
triphenylethylene compounds under the SERM family (NOLVAMED
20 (Tamoxifen citrate), CLOMIMED
50 (Clomiphene citrate), and Toremifene) also exhibit Estrogen agonistic effects in the liver,
meaning the liver is one such area of the body where SERMs such as CLOMIMED
50 (Clomiphene citrate), will act as
an Estrogen rather than block Estrogenic activity there. Estrogens and Estrogen
agonists (such as CLOMIMED
50 (Clomiphene citrate), impart a positive effect on cholesterol values through actions in the
liver. Because of that effect, the reduction of Estrogen levels through the use
of an aromatase inhibitor (AI) is not always the best decision, as the
reduction in Estrogen levels results in increase
plasma cholesterol.
Chemical
Characteristics of CLOMIMED 50 (Clomiphene citrate)
CLOMIMED
50 (Clomiphene citrate) is a non-steroidal selective Estrogen receptor modulator (SERM)
that possesses both mixed agonistic as well as antagonistic properties
concerning Estrogen in different areas of the body. CLOMIMED
50 (Clomiphene citrate) is part of a family of compounds known as triphenylethylene compounds. NOLVAMED
20 (Tamoxifen citrate) also belongs to the same group and is a very closely related compound
to CLOMIMED
50 (Clomiphene citrate).
Properties
of CLOMIMED 50 (Clomiphene citrate)
In the medical
field CLOMIMED
50 (Clomiphene citrate) is primarily
utilized as a fertility drug in females but
also among males as well. CLOMIMED
50 (Clomiphene citrate), being a SERM, does not reduce circulating Estrogen levels in the body,
opposite it serves to occupy the receptor sites in breast tissue so that
Estrogen itself cannot bind to these receptors thanks to CLOMIMED
50 (Clomiphene citrate) stronger binding strength to it. CLOMIMED
50 (Clomiphene citrate) acts as a ‘fake’ Estrogen that acts as a placeholder at the receptor
sites in breast tissue. Because of those actions, Estrogen cannot activate gene
transcription in the cells there to formulate gynecomastia, and any existing
Estrogen that has already bound to receptor sites will essentially be ‘forced’
out of the receptor sites by CLOMIMED
50 (Clomiphene citrate) which then occupies the receptor site instead.
CLOMIMED
50 (Clomiphene citrate) is very effective as an endogenous Testosterone production
stimulating compound. This is the main function ofCLOMIMED
50 (Clomiphene citrate) among the anabolic steroid using athletes and bodybuilders. As a SERM, CLOMIMED
50 (Clomiphene citrate) will not serve to block or reduce any other Estrogenic side
effects, however, as it serves only to block Estrogenic activity at the breast
tissue area (when major Estrogenic side effects are concerned).
The same like any other SERMs, CLOMIMED
50 (Clomiphene citrate) does not serve to reduce bloating, water retention, rising blood
pressure (as a result of water retention), or acne formation – these are all
side effects resultant from increasing blood plasma Estrogen levels.
CLOMIMED 50
(Clomiphene citrate) Side Effects
CLOMIMED
50 (Clomiphene citrate) is part of the SERM family of medications, Most
people tolerate well with this drug, but like any other medication, there is
the risk of possible side effects.
CLOMIMED
50 (Clomiphene citrate) is anti-estrogenic. It’s utilized
as a fertility drug. Many anabolic steroid users rely on CLOMIMED
50 (Clomiphene citrate) to lessen or eliminate typical steroid side
effects. CLOMIMED
50 (Clomiphene citrate) is not a steroidal drug. CLOMIMED
50 (Clomiphene citrate) may cause such side effects as
headaches, nausea and hot flashes. Also, that happens very rarely, but CLOMIMED
50 (Clomiphene citrate) may cause uterine bleeding in
women. Female users of CLOMIMED
50 (Clomiphene citrate) sometimes may notice discomfort in their breasts.
Studies show
that one and a half percent of people who utilize CLOMIMED
50 (Clomiphene citrate) experience visual disturbances: their vision may become hazy or blurry.
If that happens, that is necessary to stop using CLOMIMED
50 (Clomiphene citrate). Those visual disturbances will disappear when a person stops taking CLOMIMED
50 (Clomiphene citrate).
Another possible side effect is acne
– people who use the drug during anabolic steroid post-cycle therapy (PCT), may
be likely to develop pimples. CLOMIMED
50 (Clomiphene citrate) can be the reason for the development
of acne, which may appear on the shoulders, chest or back, whether the user is
involved with anabolic steroids or not.
Dosages and
Administration of CLOMIMED 50 (Clomiphene citrate)
CLOMIMED
50 (Clomiphene citrate) is available in pill format. Most women who take the drug due to
infertility problems take fifty milligrams of CLOMIMED
50 (Clomiphene citrate) per day. The dosing schedule for women with fertility problems is one
dose a day for five days in a row. If the desired effect doesn’t appear, the
dosage may be upped to one hundred milligrams per day. Dosage usually begins
five days into a female’s menstrual cycle. This type of cycle will repeat five
or six times until the women become pregnant. In case the woman doesn’t become
pregnant during that time, the treatment with CLOMIMED
50 (Clomiphene citrate) is stopped.
Anabolic
steroids users usually take fifty milligrams of the drug, just as women who
want to conceive do. Steroids users will take fifty milligrams all through
their cycles. In case they don’t get good estrogenic protection from CLOMIMED
50 (Clomiphene citrate), they may find that upping their dosages doesn’t
change anything. That is worth to try another drug - steroid users can get
better results with another SERM, such as NOLVAMED
20 (Tamoxifen citrate) or ARIMIMED
1 (Anastrozole).
For post-cycle
therapy, steroid users generally begin taking one hundred to one hundred and
fifty milligrams of CLOMIMED
50 (Clomiphene citrate)per day, for one to two weeks. After that period, the dosage per day is
usually dropped to fifty milligrams per day, or one hundred milligrams if the
previous dosage was one hundred and fifty milligrams. The lower dosage is taken
for one to two weeks.
In
general, CLOMIMED
50 (Clomiphene citrate) should be taken for four to six
weeks. Dosage schedules should take that timeline into account. For post-cycle
therapy, a lot of steroid users find that combining CLOMIMED
50 (Clomiphene citrate) therapy with HCG and Nolvadex
brings great results. The inclusion of HCG will impact the timing of CLOMIMED
50 (Clomiphene citrate) usage.
Timing
is very important: if a cycle concludes with anabolic steroids that have large
ester bases, you should start taking CLOMIMED
50 (Clomiphene citrate) a couple of weeks after your final injection. If
your cycle concludes with anabolic steroids with small ester bases, you should
start taking CLOMIMED
50 (Clomiphene citrate) three days after your final
injection. If your cycle concludes with anabolic steroids with large ester
bases, you should start HCG ten days after your final injection and then start CLOMIMED
50 (Clomiphene citrate) once therapy with HGG concludes. If your cycle
finishes with anabolic steroids which have small ester bases, you should start
HCG three days after your final injection and then start CLOMIMED
50 (Clomiphene citrate) after therapy with HCG concludes.
Chemical info / Information
Clomiphene Citrate (AKA Clomid)
Chemical Name: 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamine
Molecular Weight: 406 g/mol or 598.10 g/mol (citrate salt)
Formula: C26H28ClNO
Original Manufacturer:
Elimination
half-life: 5 – 7 days (some reports as long as 14 days)
Detection Time: 2 months
Anabolic Rating: N/A Androgenic
Rating: N/A
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