Overview and History of ANADROMED 50 (Oxymetholone)

ANADROMED 50 (Oxymetholone) is known as one of the strongest oral anabolic steroid available. The steroid-using bodybuilding community has been always debated about ANADROMED 50 (Oxymetholone) and its main competitor DIANAMED 10 (Methandienone), which of these two steroids is stronger.

ANADROMED 50 is the trade name for the anabolic steroid more formally known as Oxymetholone. Oxymetholone firstly was released in 1959 under the brand name Anadrol. Almost immediately after it was launched, the pharmaceutical company Syntex sold Oxymetholone under the name Anadrol-50 while Parke Davis & Co. also manufactured it under the Androyd trade name. After its release onto prescription markets, ANADROMED 50 (Oxymetholone) was quickly started to be utilized for various medical conditions ranging from geriatric atrophy to combating infections. It’s most popular use as medication was in the treatment of anemia. ANADROMED 50 (Oxymetholone) was prescribed to increase the red blood cell count and hemoglobin levels of the anemic individual.  This compound is a good help for such condition because of its ability to stimulate erythropoiesis at a very high rate. Although all anabolic steroids exhibit this capability, ANADROMED 50 (Oxymetholone) ability to stimulate erythropoiesis are greater than any other anabolic steroid.

Studies have shown that ANADROMED 50 (Oxymetholone) can increase red blood cell production by a factor of 5 fold. ANADROMED 50 (Oxymetholone) is a very effective steroid for muscle-building purposes. Also, studies have demonstrated that it has exerted notable anabolic effects on muscle-wasting AIDS patients, causing them to gain 8kg of weight while those who were administered a placebo not only lost weight but also experienced an increase in mortality. Because of this important reason, ANADROMED 50 (Oxymetholone) is widely prescribed as prime medication for AIDS patients and muscle wasting diseases.

Chemical Characteristics of ANADROMED 50 (Oxymetholone)

ANADROMED 50 (Oxymetholone) belongs to the family of Dihydrotestosterone (DHT) derived anabolic steroids. Meaning, that ANADROMED 50 (Oxymetholone) is Dihydrotestosterone modified. Other compounds in this ‘DHT family’ of anabolic steroids include WINIMED 10 (Stanozolol), PRIMOMED 100 (Methenolone Enanthate), MASTERMED E 200 (Drostanolone Enanthate), ANAVAMED 10 (Oxandrolone), as well as several others which are all derivatives of the parent anabolic steroid DHT. All of the above mentioned DHT-derivative analogs have the common factor, all of them are modified forms of DHT and thus DHT could be considered the ‘parent’ or ‘progenitor’ hormone of these anabolic steroids.

ANADROMED 50 (Oxymetholone) is different from its parent hormone DHT by the addition of a methyl group attached to it, as well as a 2-hydroxymethylene group attached to a carbon in the first cycloalkane ring of the steroid structure. Thanks to these modifications ANADROMED 50 (Oxymetholone) remains active in muscle tissue, which is where Dihydrotestosterone would normally be rendered inactive by its reduction to other metabolites once it enters muscle tissue. The enzyme responsible for doing this to Dihydrotestosterone, which is present in large amounts in muscle tissue, is 3-hydroxysteroid dehydrogenase. With the chemical modifications mentioned, this enzyme does not interact with ANADROMED 50 (Oxymetholone). This quality allows ANADROMED 50 (Oxymetholone) to be very active in muscle tissue and lends to its very strong potency.

ANADROMED 50 (Oxymetholone) possesses an anabolic rating of 320 (a little more than 3 times the strength of Testosterone, with its anabolic rating of 100). ANADROMED 50 (Oxymetholone) also possesses reduced androgenic strength compared to that of Testosterone, where ANADROMED 50 (Oxymetholone) holds an androgenic rating of 45 (compared to Testosterone’s androgenic rating of 100).

ANADROMED 50 (Oxymetholone) contains the unique and unusual characteristics such as: although it is a derivative of DHT, it possesses a very high level of Estrogenic activity. It is typically known that all DHT-derivative anabolic steroids should be unable to convert into Estrogen via the aromatase enzyme and therefore no Estrogenic effects could be present, but things are very different with ANADROMED 50 (Oxymetholone). ANADROMED 50 (Oxymetholone) is well known for causing water retention, bloating, gynecomastia, and other Estrogenic side effects on the body even though it does not convert into Estrogen. It is believed that ANADROMED 50 (Oxymetholone) itself acts as an estrogen in certain tissues. ANADROMED 50 (Oxymetholone) is infamous for its Estrogenic effects that every potential user should be aware of. Those Estrogenic effects cannot be combated with aromatase inhibitors due to its inability to convert into Estrogen.

ANADROMED 50 (Oxymetholone) is an orally active anabolic steroid, which means it has been C17 Alpha Alkylated to allow the anabolic steroid to make the first pass through the liver without suffering destruction through liver metabolism.

Also, ANADROMED 50 (Oxymetholone) is very well known for its very harsh hepatotoxicity. ANADROMED 50 (Oxymetholone) chemical modifications and chemical structure (including its C17 Alpha Alkylation) make it very resistant to hepatic breakdown (liver metabolism). ANADROMED 50 (Oxymetholone) is regarded as the most liver toxic oral anabolic steroid conventionally available.

ANADROMED 50 (Oxymetholone) Side Effects

ANADROMED 50 (Oxymetholone) is an orally active C-17 alpha-alkylated anabolic steroid, which exhibits hepatotoxicity and negative effects on the liver. Although ANADROMED 50 (Oxymetholone) possesses a chemical modification that is supposed to reduce hepatotoxicity, in reality, ANADROMED 50 (Oxymetholone) still raises liver enzyme markers during use as demonstrated in studies with HIV and AIDS patients. It is highly recommended to limit the use of ANADROMED 50 (Oxymetholone) to cycle lengths of no greater than 4 – 6 weeks, and to supplement with plenty of proven liver support compounds.

Being a DHT (Dihydrotestosterone) derivative, ANADROMED 50 (Oxymetholone) does not convert into Estrogen. Still, Estrogenic side effects are present with ANADROMED 50 (Oxymetholone), producing side effects such as bloating and water retention (often reported as extreme) with concomitant increases in blood pressure, and the development of gynecomastia. The use of a SERM (for example NOLVAMED 20 (Tamoxifen citrate)) will mitigate gynecomastia, but it is not going to solve water retention (and resultant blood pressure) issues.

Aromatase inhibitors will not work together with ANADROMED 50 (Oxymetholone), because it has no interaction with the aromatase enzyme. There are assumptions that ANADROMED 50 (Oxymetholone) may act as a Progestin causing these side effects, but studies have demonstrated that ANADROMED 50 (Oxymetholone)  does not hold any Progestogenic properties. The most realistic explanation would be that ANADROMED 50 (Oxymetholone)  may interact with the Estrogen receptor directly, or that a metabolite of ANADROMED 50 (Oxymetholone)  might do this as well.

But that is not all - sometimes ANADROMED 50 (Oxymetholone)  has very strange side effects. For example, androgenic side effects, which tend to be fairly reduced in comparison with Testosterone. ANADROMED 50 (Oxymetholone) does not convert into DHT and instead is metabolized into 17-alpha-methyl dihydrotestosterone (Mestanolone). Mestanolone is a stronger androgen, that is why some androgenic side effects can be presented with ANADROMED 50 (Oxymetholone). This includes oily skin, acne, male pattern baldness, benign prostatic hyperplasia, etc. The same like all other oral anabolic steroids, ANADROMED 50 (Oxymetholone) tends to impact the cardiovascular system negatively in an extreme manner, producing vast alterations in blood cholesterol profiles (for both LDL and HDL).

ANADROMED 50 (Oxymetholone) Cycles and Use

ANADROMED 50 (Oxymetholone)  cycles are usually intended for bulking, strength-gaining, and general overall mass. ANADROMED 50 (Oxymetholone) cycles are not suited for cutting, fat loss, pre-contest, or similar things. ANADROMED 50 (Oxymetholone) can be used as a help to accelerate fat loss; but it is a bad choice because of its Estrogenic effects, such as water retention and bloating. The aromatase inhibitor would also not work to reduce this bloating effect.

ANADROMED 50 (Oxymetholone) cycles are normally composed of ANADROMED 50 (Oxymetholone)  as a kickstarting compound for the first 4 – 6 weeks where it is supplementary to other injectable base compounds that are used for similar purposes, such as TESTOMED E 250 (Testosterone Enanthate), DECAMED 250 (Nandrolone Decanoate), TRENBOMED E 200 (Trenbolone Enanthate), etc. ANADROMED 50 (Oxymetholone) can be used in the middle of a cycle to push through any stumbling blocks in training progress. Sometimes users put ANADROMED 50 (Oxymetholone) in the end of a cycle in order to boost the end of a cycle and act as a ‘finisher’ compound in a cycle, leaving the user to end off their cycle with some very impressive strength and size gains as they move into the PCT (Post Cycle Therapy) phase.

ANADROMED 50 (Oxymetholone) cycles should not extend beyond 4 – 6 weeks because of its hepatotoxicity issues. Other compounds used with ANADROMED 50 (Oxymetholone), such as injectables, can be utilized beyond ANADROMED 50 (Oxymetholone) ending period.

Dosages and Administration of ANADROMED 50 (Oxymetholone)

ANADROMED 50 (Oxymetholone) dosage is varied and is dependent on the medical condition treated, as well as constantly changing FDA guidelines. Medical dosages of ANADROMED 50 (Oxymetholone) are ranged from 2.5mg taken three times per day up to 30mg.

ANADROMED 50 (Oxymetholone) is most commonly manufactured in 50mg tablets. Therefore the dosage for bodybuilding and athletic purposes is 25 – 50mg per day for a beginner. Intermediate users are known for using a range of 50 – 100mg per day, and advanced users take a high dose of 150mg per day (those users must be very careful, as this dosage approaching risky limits). Most of the users, no matter if that is beginner, intermediate, or advanced user, should seldom require more than 50mg per day because of the strength of ANADROMED 50 (Oxymetholone) is an anabolic steroid.

Also, many users report a reduction in appetite directly proportional to the dose utilized, and studies have shown that ANADROMED 50 (Oxymetholone) increases glucose intolerance and insulin resistance, thus making nutrient use by the body less efficient. ANADROMED 50 (Oxymetholone) dosages can and should ideally be split throughout the day to ensure stable and steady blood plasma levels of the hormone. ANADROMED 50 (Oxymetholone) exhibits a half-life of about 8 to 9 hours in the body, and therefore a schedule involving a morning (AM) dose followed by an afternoon/evening (PM) dose is best.


Chemical info / Information
Oxymetholone (AKA Anadrol, Anadrol-50)
Chemical Name: 17β-hydroxy-2-hydroxymethylene-17-methyl-5α-androstan-3-one
Molecular Weight: 332.48 g/mol
Formula: C21H32O3
Original Manufacturer: Syntex
Elimination half-life: 8 – 9 hours
Detection Time: 2 months
Anabolic Rating: 320
Androgenic Rating: 45