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Overview and History of DIANAMED 10 (Methandienone)
DIANAMED 10 (Methandienone) is known by its scientific and chemical name as Methandrostenolone or Methandienone. Today that is the most popular anabolic steroid which is widely used among bodybuilders and athletes.
DIANAMED 10 (Methandienone) became popular in the late 1950s and throughout the “Golden Era of Bodybuilding” of the 1960s and 1970s. Methandienone was introduced to the pharmaceutical and medical community by Dr. John Ziegler. At that time this compound was developed as an American response to the Soviet Union use of Testosterone in their Olympic athletes. Methandienone was introduced to the prescription market under the brand name of Dianabol by the Ciba pharmaceutical company. At that time it was the first orally active anabolic steroid to be synthesized and sold on the prescription market.
DIANAMED 10 (Methandienone) possesses a half-life of 4.5 – 6 hours, contains a moderate level of Estrogenic effects in the body and has less of a rate of conversion into a stronger androgenic metabolite via the 5-alpha-reductase enzyme. Because of these reasons DIANAMED 10 (Methandienone) is a very popular choice among bodybuilders and athletes. Above all else, this compound is utilized for mass and strength.
Chemical Characteristics of DIANAMED 10 (Methandienone)
DIANAMED 10 (Methandienone) is methylated at carbon 17-alpha on its structure (this is simply the addition of a methyl group at the 17th carbon). This process is known as C17-Alpha Alkylation, and it allows the anabolic steroid to be administered orally and still have a measurably strong effect on the body.
It wouldn’t be possible for any anabolic steroid to survive liver metabolism without this modification. It allows surviving liver metabolism in significant enough quantities to promote any measurable effects on the body – the result is that extremely minuscule amounts of the anabolic steroid reach the bloodstream to perform its job.
DIANAMED 10 (Methandienone) possesses a double-bond between carbons 1 and 2. This modification, in particular, is what grants it a ‘milder' androgenic strength in comparison to its parent hormone Testosterone. This double-bond is what limits DIANAMED 10 (Methandienone) affinity to bind to the androgen receptor in different tissues in comparison to Testosterone. Because of these modifications, DIANAMED 10 (Methandienone) half-life exceeds that of Testosterone (Dianabol’s half-life is 4.5 – 6 hours). Also, these chemical modifications have an additional benefit that is DIANAMED 10 (Methandienone) lower affinity for binding proteins to bind to it, such as Sex Hormone Binding Globulin (SHBG). These binding globulins (in this case SHBG), which are proteins, bind to sex hormones such as Testosterone, Estrogen, Dianabol, etc. and render them inactive temporarily. What results that a bound hormone that floats around in the bloodstream and does nothing – it cannot bind to receptors and is useless.
DIANAMED 10 (Methandienone) possesses a weaker interaction with the androgen receptor in comparison to Testosterone and many other anabolic steroids, but still, it is a very strong and potent hormone in comparison with others. A big part of DIANAMED 10 (Methandienone) activity is that of non-receptor mediated activity.
DIANAMED 10 (Methandienone) anabolic rating is 210 in comparison with Testosterone’s anabolic rating of 100. Meaning that DIANAMED 10 (Methandienone) possesses slightly over double the anabolic strength of Testosterone, and this is because of the previously described structural modifications it possesses.
The Effects of DIANAMED 10 (Methandienone)
There is the negative downside of DIANAMED 10 (Methandienone) being C17-Alpha Alkylated steroid. C17-Alpha Alkylation allows an anabolic steroid to become more resistant to hepatic breakdown. An oral steroid that is 17 alpha-alkylated will be able to pass through the liver without being destroyed by it. As a result, many users will use it for a 4-6 week at a given time. This is to ensure healthy liver function, and for proper liver recovery following the cycle. It is very common to see an elevation in liver enzymes while using DIANAMED 10 (Methandienone) and then a recovery following cessation. It is because of the risk of hepatotoxicity that DIANAMED 10 (Methandienone) main function in a cycle has been to serve as a supportive kickstarting compound.
DIANAMED 10 (Methandienone), the same as any other oral anabolic steroid, should never be run solitarily on its own. It suppresses natural testosterone and hence leaves the user without any testosterone in their body. Users will use testosterone in some form, no lower than a TRT (Testosterone Replacement Therapy) dose. DIANAMED 10 (Methandienone) contains moderate Estrogenic activity and is a compound that is exposed to aromatization by the aromatase enzyme, which is the enzyme responsible for converting androgens into Estrogen.
This is the reason why DIANAMED 10 (Methandienone) is widely known for its Estrogenic side effects of water retention, risk of gynecomastia, elevated blood pressure (often as a result of water retention), and possible fat retention/gain due to Estrogen.
DIANAMED 10 (Methandienone) expresses far less androgenic strength and activity than Testosterone, but it is very important to realize that androgen-related side effects and issues can still happen during the use of DIANAMED 10 (Methandienone). DIANAMED 10 (Methandienone) possesses an androgenic rating of 40-60 while Testosterone’s androgenic rating is 100. Anyway, the risk of androgenic side effects is still present especially in those individuals sensitive to androgenic side effects. Androgenic side effects can include: increased risk for male pattern baldness (MPB) if the individual possesses the genetic trait responsible for it, increased sebum secretion (oily skin) and associated acne, and increased facial hair and bodily hair growth.
Besides, the 5-Alpha Reductase enzyme which is the enzyme responsible for converting Testosterone into the much stronger androgen Dihydrotestosterone (DHT) does also interact with DIANAMED 10 (Methandienone). Then it happens, Dihydrotestosterone is not created but instead, DIANAMED’S 10 (Methandienone) own more androgenic metabolite is the result. A positive aspect of that is that DIANAMED 10 (Methandienone) possesses a lower binding affinity for the 5-Alpha Reductase enzyme.
DIANAMED 10 (Methandienone) Side Effects
The side effects of DIANAMED 10 (Methandienone) are variable. The most significant side effect of DIANAMED 10 (Methandienone) is that of estrogen-related effects including water retention and bloating meaning this oral steroid will increase blood pressure as well, acne and gynecomastia (development of breast tissue). The most common side effect of DIANAMED 10 (Methandienone) tends to be the bloating and water retention, followed by gynecomastia.
DIANAMED 10 (Methandienone) can also produce androgenic side effects as well. There are risks of experiencing acne, oily skin, male pattern baldness, and benign prostatic hyperplasia. There is one more concerning side effect of DIANAMED 10 (Methandienone) - its increased stress imposed on the hepatic system (i.e. the liver). Cycle lengths exceeding 4 – 6 weeks can be extremely liver for the liver. To lower the risk of such side effects, the user should use liver support compounds; avoid high dosages and other drugs that can stress the liver.
DIANAMED 10 (Methandienone) is known for its strong inhibitive nature on the HPTA (Hypothalamic Pituitary Testicular Axis). Clinical studies have been conducted on DIANAMED’S 10 (Methandienone) testosterone inhibitive action in humans, and they have shown that doses as low as 15mg per day for 8 weeks caused total plasma Testosterone levels to decline by 69%.
DIANAMED 10 (Methandienone) also has those side effects that are also typical with any anabolic steroid. This includes negative cholesterol alterations, negative cardiovascular effects, and disruption of the HPTA (Hypothalamic Pituitary Testicular Axis).
DIANAMED 10 (Methandienone) Cycles and Use
DIANAMED 10 (Methandienone) cycles are very straightforward in most cases of its application. DIANAMED 10 (Methandienone) is usually utilized during periods of bulking and strength gaining where the bodybuilder or athlete is not overly concerned with water retention and bloating.
Such types of DIANAMED 10 (Methandienone) cycles are therefore normally during the "off-season" period where bodybuilders are achieving this goal, and it is normally cycled with some kind of injectable anabolic steroid that achieves similar results – normally some variant of Testosterone, such as Testosterone Enanthate.
Most of these DIANAMED 10 (Methandienone) cycles involve its use as a kickstarting compound, where it is used only during the first 4 – 6 weeks of the cycle in order to experience strength and size gains while the user waits for the longer-acting injectable compound (i.e. Testosterone Enanthate) to achieve its full effects and “kick in”. DIANAMED 10 (Methandienone) shouldn’t be used for longer than 4 – 6 weeks due to its nature as a C-17 alpha-alkylated compound, which exerts negative effects on the liver (and especially cholesterol levels).
DIANAMED 10 (Methandienone) is very rarely employed as a cutting or fat loss agent, although some users can do that. That is better to avoid this, because of DIANAMED’S 10 (Methandienone) negative estrogenic effects (such as water retention and bloating). DIANAMED 10 (Methandienone) cycles intended for cutting or fat loss are generally run the same way as previously outlined cycles, as fat loss is first and foremost achieved through the athlete’s diet and nutritional intake and not determined by which anabolic steroid is utilized.
Dosages and Administration of DIANAMED 10 (Methandienone)
DIANAMED 10 (Methandienone) is considered a very potent anabolic steroid where anabolism (the buildup of muscle tissue) is concerned. Therefore, its dosages need not be as high as many other commonly used oral anabolic steroids.
DIANAMED 10 (Methandienone) dosages need to be considered very carefully especially in the cases where negative effects on the liver are concerned. Bear in mind, that the higher dosage is used the hire is a corresponding increase in the negative effects.
Dr. Ziegler originally issued prescription guidelines of 5mg per day for no longer than 6 weeks. Being that 5mg is on the lowest end of the dosage spectrum, more modern DIANAMED 10 (Methandienone) beginner dosages range between 15 – 30mg per day. Intermediate and advanced dosages for DIANAMED 10 (Methandienone) are in the area of 30 – 50mg per day.
Female DIANAMED 10 (Methandienone) dosages are not known because DIANAMED 10 (Methandienone) is not a commonly used anabolic steroid by female athletes due to its unsuitability as a result of harsher virilization effects on the female physiology. Those female users that do venture into DIANAMED 10 (Methandienone) use have been known to utilize 2.5 – 5mg per day, and 10mg daily being the uppermost limit. Be careful as these dosages can produce very dramatic results for the few female users that exist.
Chemical info / Information
Methandrostenolone (AKA Dianabol)
Chemical Name: 17a-methyl-17b-hydroxy-1,4-androstadien-3-one
Molecular Weight: 300.441 g/mol
Original Manufacturer: Ciba (originally)
Elimination half-life: 4.5 – 6 hours
Detection Time: 5 – 6 weeks
Anabolic Rating: 90 – 210
Androgenic Rating: 40 – 60