How to improve the effectiveness of injections

The administration of PEDs by injection can be influenced by several factors, affecting both their pharmacokinetics (how the body affects the drug) and their pharmacodynamics (how the drug affects the body). 


Musculature and Injection Site: 

The pharmacokinetic profile of a substance varies depending on the muscle into which it is injected. 

This is due to differences in the vascularization and density of muscle tissue. For example: - 

-Injections into Densely Vascularized Muscles: Such as the deltoid or vastus lateralis, can lead to faster absorption of the substance due to increased blood circulation. 

-Injections into Muscles with Less Vascularization: May result in a slower and more prolonged release of the substance. 


Type of Oil and Viscosity

The viscosity of the carrier (such as oil, water or for example B12) in which the substance is dissolved can influence the rate of absorption. - 

Less Viscous Oils: They are generally better tolerated and can allow faster and more homogeneous absorption of the substance. - 

More Viscous Oils: They can delay the release of the drug, leading to a longer lasting effect, that’s why usually Testosterone Undecanoate oftly comes in a super dense oil, to make its absorption rate even slower.


Substance Concentration

The dose and concentration of the injected substance are quite important. 

Higher concentrations may lead to faster absorption, but may also increase the risk of local irritation and other side effects, thats why we dont carry high mg/mg products.


EXAMPLE: GH

-GH is usually reconstituted with bacteriostatic water, since its not viscous at all its absorption rate will be fast.


Type of Administration: 

-Intramuscular GH injections: it will provide a more favorable pharmacokinetic and pharmacodynamic profile for improving body composition. This is due to faster absorption and a higher peak plasma concentration, as stated earlier we can inject it on a densely vascularized muscle, like the shoulder, so we can improve the absorption speed, this is the common method recommended for serum GH bloodwork.

Subcutaneous GH injections: Although slower in terms of absorption, they may be preferred for certain treatments where a more sustained release of the hormone is sough. 

In summary, the choice of the injection site, the type of oil and its viscosity, the concentration of the substance and the method of administration are crucial factors that determine the effectiveness and safety of injection therapy. Ideally, a method is sought that provides an optimal pharmacokinetic profile, better tolerance, and minimal side effects.