Overview and History of CLOMIMED 50 (Clomiphene citrate)

CLOMIMED 50 (Clomiphene citrate) belongs to a category of drugs known as selective Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators are a diverse group which belongs to an even broader class of drugs which act on the estrogen receptor (ER). Another subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as AROMAMED 25 (Exemestane) and ARIMIMED 1 (Anastrozole). AIs and SERMs make up anti-estrogens. Aromatase inhibitors (AIs) are very different from SERMs in their action and how they deal with the issues of estrogen control.

CLOMIMED 50 (Clomiphene citrate) is classified as an anti-Estrogen, but in reality, it is utilized for the treatment of female infertility resulting from ovulation failure (anovulatory infertility). Meaning, CLOMIMED 50 (Clomiphene citrate) primarily used in medicine as a non-steroidal ovulatory stimulant for women. CLOMIMED 50 (Clomiphene citrate) is a SERM, the same like NOLVAMED 20 (Tamoxifen citrate) and it exhibits mixed Estrogen agonist and antagonist effects in various tissues of the body. Both NOLVAMED 20 (Tamoxifen citrate) and CLOMIMED 50 (Clomiphene citrate) act as an Estrogen antagonist in the hypothalamus, pituitary gland, ovaries, endometrium, vagina, and cervix. CLOMIMED 50 (Clomiphene citrate) serves to mitigate (inhibit or block) the action of Estrogen in these tissues and areas of the body. In both, males and females, its Estrogen antagonistic effect on the hypothalamus will trigger a release of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone). These two hormones in men are the signal hormones that signal the testes to begin or increase its production of Testosterone, and this total process is known as the HPTA (Hypothalamic Pituitary Testicular Axis). That is almost the same with female users, except LH and FSH will trigger the release of eggs from the ovaries (known as follicular rupture), which would lead to increased chances of contraception. This total process in females is known as the HPOA (Hypothalamic Pituitary Ovarian Axis).

Again, both NOLVAMED 20 (Tamoxifen citrate) and CLOMIMED 50 (Clomiphene citrate) could be considered an Estrogen that acts as a ‘fake’ Estrogen in areas of the body, such as breast tissue (the aim is to block the effects of ‘real’ Estrogen, while it also works as an actual Estrogen in other areas of the body). For athletes and bodybuilders that are for most males, CLOMIMED 50 (Clomiphene citrate) can serve as an effective anti-Estrogen to mitigate one particular unwanted side effect of Estrogen as a result of the use of aromatizable anabolic steroids (such as TESTOMED E 250 (Testosterone Enanthate), DIANAMED 10 (Methandienone), EQUIMED 250 (Boldenone undecylenate), etc.). This unwanted side effect is gynecomastia, which refers to the development of breast tissue resulting from excess Estrogen levels in the body. CLOMIMED 50 (Clomiphene citrate) antagonistic effects on the hypothalamus resulting in the increased production of gonadotropins LH and FSH, that is the reason CLOMIMED 50 (Clomiphene citrate) can effectively be used to increase endogenous testosterone production in males. This is especially so for the anabolic steroid using individuals that want to restore proper hormonal function during the weeks of Post Cycle Therapy (PCT). Usually, during PCT a combination of NOLVAMED 20 (Tamoxifen citrate), CLOMIMED 50 (Clomiphene citrate), and HCG (Human Chorionic Gonadotropin) is used for several weeks, and although much better more modern protocols have been developed, this long-standing traditional PCT protocol is still very effective.

All of the triphenylethylene compounds under the SERM family (NOLVAMED 20 (Tamoxifen citrate), CLOMIMED 50 (Clomiphene citrate), and Toremifene) also exhibit Estrogen agonistic effects in the liver, meaning the liver is one such area of the body where SERMs such as CLOMIMED 50 (Clomiphene citrate),  will act as an Estrogen rather than block Estrogenic activity there. Estrogens and Estrogen agonists (such as CLOMIMED 50 (Clomiphene citrate), impart a positive effect on cholesterol values through actions in the liver. Because of that effect, the reduction of Estrogen levels through the use of an aromatase inhibitor (AI) is not always the best decision, as the reduction in Estrogen levels results in increase plasma cholesterol.

Chemical Characteristics of CLOMIMED 50 (Clomiphene citrate)

CLOMIMED 50 (Clomiphene citrate) is a non-steroidal selective Estrogen receptor modulator (SERM) that possesses both mixed agonistic as well as antagonistic properties concerning Estrogen in different areas of the body. CLOMIMED 50 (Clomiphene citrate) is part of a family of compounds known as triphenylethylene compounds. NOLVAMED 20 (Tamoxifen citrate) also belongs to the same group and is a very closely related compound to CLOMIMED 50 (Clomiphene citrate).

Properties of CLOMIMED 50 (Clomiphene citrate)

In the medical field CLOMIMED 50 (Clomiphene citrate) is primarily utilized as a fertility drug in females but also among males as well. CLOMIMED 50 (Clomiphene citrate), being a SERM, does not reduce circulating Estrogen levels in the body, opposite it serves to occupy the receptor sites in breast tissue so that Estrogen itself cannot bind to these receptors thanks to CLOMIMED 50 (Clomiphene citrate) stronger binding strength to it. CLOMIMED 50 (Clomiphene citrate) acts as a ‘fake’ Estrogen that acts as a placeholder at the receptor sites in breast tissue. Because of those actions, Estrogen cannot activate gene transcription in the cells there to formulate gynecomastia, and any existing Estrogen that has already bound to receptor sites will essentially be ‘forced’ out of the receptor sites by CLOMIMED 50 (Clomiphene citrate) which then occupies the receptor site instead.

CLOMIMED 50 (Clomiphene citrate) is very effective as an endogenous Testosterone production stimulating compound. This is the main function of CLOMIMED 50 (Clomiphene citrate) among the anabolic steroid using athletes and bodybuilders. As a SERM, CLOMIMED 50 (Clomiphene citrate) will not serve to block or reduce any other Estrogenic side effects, however, as it serves only to block Estrogenic activity at the breast tissue area (when major Estrogenic side effects are concerned).

The same like any other SERMs, CLOMIMED 50 (Clomiphene citrate) does not serve to reduce bloating, water retention, rising blood pressure (as a result of water retention), or acne formation – these are all side effects resultant from increasing blood plasma Estrogen levels.

CLOMIMED 50 (Clomiphene citrate) Side Effects

CLOMIMED 50 (Clomiphene citrate) is part of the SERM family of medications, Most people tolerate well with this drug, but like any other medication, there is the risk of possible side effects.

CLOMIMED 50 (Clomiphene citrate) is anti-estrogenic. It’s utilized as a fertility drug. Many anabolic steroid users rely on CLOMIMED 50 (Clomiphene citrate) to lessen or eliminate typical steroid side effects. CLOMIMED 50 (Clomiphene citrate) is not a steroidal drug. CLOMIMED 50 (Clomiphene citrate) may cause such side effects as headaches, nausea and hot flashes. Also, that happens very rarely, but CLOMIMED 50 (Clomiphene citrate) may cause uterine bleeding in women. Female users of CLOMIMED 50 (Clomiphene citrate) sometimes may notice discomfort in their breasts.

Studies show that one and a half percent of people who utilize CLOMIMED 50 (Clomiphene citrate) experience visual disturbances: their vision may become hazy or blurry. If that happens, that is necessary to stop using CLOMIMED 50 (Clomiphene citrate). Those visual disturbances will disappear when a person stops taking CLOMIMED 50 (Clomiphene citrate).

Another possible side effect is acne – people who use the drug during anabolic steroid post-cycle therapy (PCT), may be likely to develop pimples. CLOMIMED 50 (Clomiphene citrate) can be the reason for the development of acne, which may appear on the shoulders, chest or back, whether the user is involved with anabolic steroids or not.

Dosages and Administration of CLOMIMED 50 (Clomiphene citrate)

CLOMIMED 50 (Clomiphene citrate) is available in pill format. Most women who take the drug due to infertility problems take fifty milligrams of CLOMIMED 50 (Clomiphene citrate) per day. The dosing schedule for women with fertility problems is one dose a day for five days in a row. If the desired effect doesn’t appear, the dosage may be upped to one hundred milligrams per day. Dosage usually begins five days into a female’s menstrual cycle. This type of cycle will repeat five or six times until the women become pregnant. In case the woman doesn’t become pregnant during that time, the treatment with CLOMIMED 50 (Clomiphene citrate) is stopped.

Anabolic steroids users usually take fifty milligrams of the drug, just as women who want to conceive do. Steroids users will take fifty milligrams all through their cycles. In case they don’t get good estrogenic protection from CLOMIMED 50 (Clomiphene citrate), they may find that upping their dosages doesn’t change anything. That is worth to try another drug - steroid users can get better results with another SERM, such as NOLVAMED 20 (Tamoxifen citrate) or ARIMIMED 1 (Anastrozole).

For post-cycle therapy, steroid users generally begin taking one hundred to one hundred and fifty milligrams of CLOMIMED 50 (Clomiphene citrate)per day, for one to two weeks. After that period, the dosage per day is usually dropped to fifty milligrams per day, or one hundred milligrams if the previous dosage was one hundred and fifty milligrams. The lower dosage is taken for one to two weeks.

In general, CLOMIMED 50 (Clomiphene citrate) should be taken for four to six weeks. Dosage schedules should take that timeline into account. For post-cycle therapy, a lot of steroid users find that combining CLOMIMED 50 (Clomiphene citrate) therapy with HCG and Nolvadex brings great results. The inclusion of HCG will impact the timing of CLOMIMED 50 (Clomiphene citrate) usage.

Timing is very important: if a cycle concludes with anabolic steroids that have large ester bases, you should start taking CLOMIMED 50 (Clomiphene citrate) a couple of weeks after your final injection. If your cycle concludes with anabolic steroids with small ester bases, you should start taking CLOMIMED 50 (Clomiphene citrate) three days after your final injection. If your cycle concludes with anabolic steroids with large ester bases, you should start HCG ten days after your final injection and then start CLOMIMED 50 (Clomiphene citrate) once therapy with HGG concludes. If your cycle finishes with anabolic steroids which have small ester bases, you should start HCG three days after your final injection and then start CLOMIMED 50 (Clomiphene citrate) after therapy with HCG concludes.


Chemical info / Information
Clomiphene Citrate (AKA Clomid)
Chemical Name: 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamine
Molecular Weight: 406 g/mol or 598.10 g/mol (citrate salt)
Formula: C26H28ClNO
Original Manufacturer:
Elimination half-life: 5 – 7 days (some reports as long as 14 days)
Detection Time: 2 months
Anabolic Rating: N/A   
Androgenic Rating: N/A