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What is IGF-1 DES?
IGF-1 DES is the short-acting, site-specific version. It clears in under half an hour, which is why it is injected into the muscle you have just trained.
Also sold as DES(1-3) IGF-1 or IGF-DES.
DES is IGF-1 with the first three amino acids removed. That makes it far less able to bind the proteins that normally hold IGF-1 inactive, so locally it is several times more potent than the natural molecule, and it clears within about half an hour. The short life is the point: it acts where you inject it rather than everywhere.
IGF-1 DES benefits
- Several times more potent locally than natural IGF-1
- Clears in about 30 minutes, so the effect stays near the injection site
- Injected into the muscle trained that session, for a targeted effect
- Lower systemic blood sugar risk than LR3, because it does not circulate long
IGF-1 DES dosage
- Standard
- 50 to 150mcg per injection
- Timing
- Immediately post-training
- Route
- Intramuscular, into the muscle just trained
- Half-life
- About 30 minutes
- Run length
- 4 weeks, then a break
- After injecting
- Eat carbohydrate
Injected into the muscle you have just worked, immediately after the session. That is the entire protocol and the reason to choose DES over LR3.
The blood sugar drop is smaller than with LR3 because it clears so fast, but it is not zero. Eat afterwards.
Reconstitute with bacteriostatic water. The reconstitution guide covers the method and the dosage calculator works out how much water to add for the dose you want.
Package content
- Vial
- 1 vial of lyophilised powder
- Peptide per vial
- 1mg
- Form
- Lyophilised powder for reconstitution
- Diluent
- Bacteriostatic water, sold separately
- Half-life
- About 30 minutes
- Brand
- Deus Medical
At 100mcg per session one vial covers ten sessions.
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Who is IGF-1 DES for?
Experienced users targeting a specific muscle group, usually a lagging one, and willing to inject into it directly after training.
For a systemic effect rather than a local one, IGF-1 LR3 is the version that stays in circulation.
How to use IGF-1 DES
Reconstitute with bacteriostatic water and refrigerate once mixed. Inject intramuscularly into the muscle trained that session, immediately afterwards, then eat.
Frequently asked questions
Why inject it into the muscle I just trained?
Because it clears in about half an hour, so most of the effect stays near where you put it. That local action is the whole reason DES exists rather than LR3.
The muscle you have just trained is also the one with the most receptor activity and blood flow, so it is where the peptide can do the most.
DES or LR3?
DES if you want a targeted effect on a specific muscle and are willing to inject into it after training. LR3 if you want a systemic effect across the whole body.
DES is also the safer of the two on blood sugar, simply because it does not stay in circulation.
Does it really make one muscle grow more?
That is the theory and it is the reason people use it. The evidence for meaningful site-specific hypertrophy in humans is thinner than the popularity of the practice suggests.
The mechanism is real. Whether it translates into visibly correcting a lagging body part is less established than most sources imply.
Do I need to worry about blood sugar?
Less than with LR3, but not none. It clears fast, so any drop is brief.
Eating carbohydrate post-training, which most people do anyway, covers it. Do not use it fasted.
Does it need PCT?
No. It is not androgenic and does not suppress testosterone.
There is nothing for a SERM to do.